Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SCD | O00767 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108821 | 0.81 | PDE9A (0.43) | PDE9ASCN9ASCN10APDE1CSCD | |
| SCHEMBL4572292 | 0.80 | CYP4F2 (0.46) | PDE9ACYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL29303182 | 0.77 | PDE9A (0.41) | PDE9ASCN9ASCN10APDE1CSCD | |
| SCHEMBL2594124 | 0.76 | KDM4E (0.48) | PDE9ASCN9ASCN10APDE1CKMT2A | |
| SCHEMBL15997907 | 0.76 | CYP11B2 (0.50) | PDE9ACYP11B2TP53SCN9ASCN10A | |
| SCHEMBL15910875 | 0.74 | PDE9A (0.43) | PDE9AGRM1PDE1C | |
| SCHEMBL28995889 | 0.73 | DDB1 (0.38) | PDE9ASCN9ASCN10APDE1CNPC1 | |
| SCHEMBL14910824 | 0.73 | DDB1 (0.57) | PDE9ASCN9ASCN10APDE1CKMT2A | |
| SCHEMBL23389349 | 0.73 | GRM1 (0.42) | PDE9AGRM1PDE1C | |
| SCHEMBL31495775 | 0.73 | DDB1 (0.50) | PDE9ATP53PDE1CNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772484-B1 | BICYCLIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-06-28 | — | — | EP | disclosed |