SCHEMBL19049075

SCHEMBL19049075

COc1cccc(CC2CN(C(C)=O)CCN2)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 1/20 0.51
OPRK1 P41145 1/20 0.47
EED O75530 2/20 0.46
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA4 P22748 2/20 0.44
CA9 Q16790 2/20 0.44
HTR1A P08908 1/20 0.44
SLC6A4 P31645 1/20 0.44
KMT2A Q03164 3/20 0.44
SIGMAR1 Q99720 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MEN1 O00255 2/20 0.42
ABCB1 P08183 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4281534 0.91 CCR3 (0.49) CCR3EEDCA1CA2CA4
SCHEMBL19002806 0.89 CCR3 (0.47) CCR3EEDCA1CA2CA4
SCHEMBL21169224 0.88 CCR3 (0.47) CCR3EEDCA1CA2CA4
SCHEMBL13705102 0.86 CCR3 (0.45) CCR3EEDCA1CA2CA4
SCHEMBL6132670 0.86 CCR3 (0.45) CCR3EEDCA1CA2CA4
SCHEMBL19049071 0.83 CA1 (0.46) CCR3CA1CA2CA4CA9
SCHEMBL19049072 0.82 CA1 (0.60) CA1CA2CA4CA9ABCB1
Hydrochloric Acid SCHEMBL6133157 0.81 RHOA (0.52) CCR3OPRK1CA1CA2CA4
SCHEMBL23222258 0.80 SLC6A4 (0.45) EEDHTR1ASLC6A4SIGMAR1KDM4E
SCHEMBL13858982 0.79 SLC6A4 (0.47) EEDHTR1ASLC6A4SIGMAR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3642209-B1 COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE SHY Therapeutics LLC (US) 2023-11-29 EP disclosed
EP-3394056-B1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC (US) 2021-04-14 EP disclosed
WO-2017112777-A1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC (US) 2017-06-29 WO disclosed