Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391647 | 0.92 | MRGPRX1 (0.44) | MRGPRX1HRH1BRAFMEN1MAPK1 | |
| SCHEMBL19050669 | 0.90 | MRGPRX1 (0.40) | MRGPRX1HRH1BRAFBRD4MEN1 | |
| SCHEMBL19050673 | 0.89 | MRGPRX1 (0.40) | MRGPRX1HRH1BRAFBRD4MEN1 | |
| SCHEMBL10251094 | 0.87 | MAP2K1 (0.48) | BRAFSLC6A2SLC6A4SLC6A3MAP2K2 | |
| SCHEMBL19050657 | 0.84 | MEN1 (0.47) | MRGPRX1HRH1BRAFBRD4MEN1 | |
| SCHEMBL14263851 | 0.81 | MAP2K2 (0.40) | MEN1MAPK1KMT2AMAP2K2MAP2K1 | |
| SCHEMBL19050690 | 0.80 | MRGPRX1 (0.41) | MRGPRX1HRH1BRAFMEN1MAPK1 | |
| SCHEMBL387927 | 0.80 | MAP2K1 (0.44) | MRGPRX1BRAFKMT2AKITMAP2K2 | |
| SCHEMBL391574 | 0.78 | MAP2K1 (0.53) | BRAFSLC6A2SLC6A4SLC6A3MAP2K2 | |
| SCHEMBL13672516 | 0.78 | KIT (0.39) | MRGPRX1BRAFKITMAP2K2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170183333-A1 | DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES AS INHIBITORS OF MEK | ARDEA BIOSCIENCES, INC. (US) | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183333-A1 | DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES AS INHIBITORS OF MEK | BRAF, NRAS, MAP3K2 | MRGPRX1 1641/4885HRH1 1890/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.