Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672910 | 0.91 | KIT (0.42) | KITMAP2K1MAP2K2BRAFALOX5AP | |
| SCHEMBL387927 | 0.87 | MAP2K1 (0.44) | KITMAP2K1MAP2K2BRAFTLR4 | |
| SCHEMBL391647 | 0.85 | MRGPRX1 (0.44) | KITMAP2K1MAP2K2BRAFTLR4 | |
| SCHEMBL391574 | 0.85 | MAP2K1 (0.53) | MAP2K1MAP2K2BRAF | |
| SCHEMBL392514 | 0.84 | MAP2K1 (0.43) | MAP2K1MAP2K2BRAFRAF1PDGFRB | |
| SCHEMBL391735 | 0.83 | KIT (0.48) | KITMAP2K1MAP2K2BRAFALOX5AP | |
| SCHEMBL392187 | 0.82 | ACLY (0.47) | KITMAP2K1MAP2K2BRAFALOX5AP | |
| SCHEMBL392180 | 0.82 | GPR119 (0.41) | KITMAP2K1MAP2K2BRAF | |
| SCHEMBL19050669 | 0.81 | MRGPRX1 (0.40) | MAP2K1MAP2K2BRAFTLR4MRGPRX1 | |
| SCHEMBL387833 | 0.81 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009129246-A2 | COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARDEA BIOSCIENCES, INC. (US) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009018233-A1 | DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME | ARDEA BIOSCIENCES, INC. (US) | 2009-02-05 | — | — | WO | disclosed |