Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19059059 | 0.91 | GPR119 (0.50) | GPR119KCNH2GPR183CHRM4FAAH | |
| SCHEMBL19059240 | 0.90 | GPR119 (0.58) | GPR119KCNH2GPR183FAAHITGB3 | |
| SCHEMBL19059325 | 0.85 | GPR119 (0.68) | GPR119KCNH2 | |
| SCHEMBL13194858 | 0.85 | GPR119 (0.68) | GPR119KCNH2 | |
| SCHEMBL15490192 | 0.85 | GPR119 (0.68) | GPR119KCNH2 | |
| SCHEMBL2898618 | 0.85 | GPR119 (0.48) | GPR119KCNH2GPR183 | |
| SCHEMBL2898615 | 0.85 | GPR119 (0.48) | GPR119KCNH2GPR183 | |
| SCHEMBL19059465 | 0.81 | GPR119 (0.69) | GPR119KCNH2 | |
| SCHEMBL19059316 | 0.81 | GPR119 (0.69) | GPR119KCNH2 | |
| SCHEMBL13194857 | 0.81 | GPR119 (0.69) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |