Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 7/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 7/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16144296 | 1.00 | GNAI3 (0.34) | GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL14317264 | 0.79 | GBA1 (0.34) | — | |
| SCHEMBL16144310 | 0.79 | GBA1 (0.34) | — | |
| SCHEMBL7989298 | 0.78 | — | — | |
| SCHEMBL16144297 | 0.78 | CYP2D6 (0.32) | GNAI3GNAO1GNAI1 | |
| SCHEMBL15706640 | 0.78 | CYP2D6 (0.32) | GNAI3GNAO1GNAI1 | |
| SCHEMBL17127010 | 0.78 | CYP2D6 (0.32) | GNAI3GNAO1GNAI1 | |
| SCHEMBL17126996 | 0.78 | CYP2D6 (0.32) | GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL21644174 | 0.77 | GBA1 (0.33) | GNAI3GNAO1GNAI1 | |
| SCHEMBL17127003 | 0.75 | GNAI3 (0.30) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780337-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME (US) | 2017-12-20 | — | — | EP | disclosed |
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |