Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | CPS1 | P31327 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437726 | 0.97 | HPGD (0.51) | KCNH2GPR119ALDH1A1HSD17B10HPGD | |
| SCHEMBL19059471 | 0.82 | KCNH2 (0.45) | KCNH2GPR119L3MBTL1FKBP1ACPS1 | |
| SCHEMBL13195634 | 0.81 | KCNH2 (0.42) | KCNH2GPR119CPS1HTR2A | |
| SCHEMBL13195630 | 0.79 | DPP4 (0.52) | KCNH2GPR119ALDH1A1HSD17B10HPGD | |
| SCHEMBL19058661 | 0.79 | NAMPT (0.40) | KCNH2GPR119CPS1HTR2A | |
| SCHEMBL19059444 | 0.77 | SMN1; SMN2 (0.62) | ALDH1A1HSD17B10HPGDKDM4EL3MBTL1 | |
| SCHEMBL14968299 | 0.77 | KMT2A (0.48) | KCNH2GPR119RAB9A | |
| SCHEMBL31481058 | 0.77 | PARP10 (0.47) | ALDH1A1KDM4ECPS1HTR2A | |
| SCHEMBL19059479 | 0.77 | KMT2A (0.38) | KCNH2GPR119ALDH1A1CPS1HTR2A | |
| SCHEMBL13195638 | 0.77 | KCNH2 (0.39) | KCNH2GPR119CPS1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |