Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 6/20 | 0.31 |
| ▸ | TPH1 | P17752 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99142 | 0.83 | SIGMAR1 (0.40) | SIGMAR1PRMT5SCN9ATPH1 | |
| SCHEMBL31089960 | 0.83 | SIGMAR1 (0.40) | SIGMAR1PRMT5SCN9ATPH1 | |
| SCHEMBL21201777 | 0.82 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ATPH1 | |
| SCHEMBL17539275 | 0.82 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ATPH1 | |
| SCHEMBL19928567 | 0.82 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ATPH1PIK3CG | |
| SCHEMBL13286173 | 0.82 | SIGMAR1 (0.46) | SIGMAR1PRMT5SCN9ACHUKTPH1 | |
| SCHEMBL17387449 | 0.81 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ATPH1 | |
| SCHEMBL871452 | 0.81 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ACHUKTPH1 | |
| SCHEMBL30749810 | 0.81 | SIGMAR1 (0.39) | SIGMAR1PRMT5SCN9ACHUKTPH1 | |
| SCHEMBL19790150 | 0.81 | SIGMAR1 (0.38) | SIGMAR1PRMT5SCN9ACHUKTPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017109524-A1 | METHOD AND INTERMEDIATE FOR THE PRODUCTION OF BARICITINIB | EGIS GYÓGYSZERGYÁR ZRT. (HU) | 2017-06-29 | — | — | WO | disclosed |