Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 15/20 | 0.58 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990944 | 1.00 | GRM5 (0.58) | GRM5CNR2FPR2NPC1RAB9A | |
| SCHEMBL990196 | 0.91 | CNR2 (0.48) | GRM5CNR2NPC1RAB9A | |
| SCHEMBL992298 | 0.91 | CNR2 (0.48) | GRM5CNR2NPC1RAB9A | |
| SCHEMBL990179 | 0.88 | GRM5 (0.46) | GRM5NPC1RAB9A | |
| SCHEMBL990855 | 0.88 | GRM5 (0.46) | GRM5NPC1RAB9A | |
| SCHEMBL990882 | 0.87 | GRM5 (0.45) | GRM5CNR2NPC1RAB9A | |
| SCHEMBL990819 | 0.87 | GRM5 (0.46) | GRM5CNR2NPC1RAB9A | |
| SCHEMBL990171 | 0.87 | GRM5 (0.46) | GRM5CNR2NPC1RAB9A | |
| SCHEMBL990845 | 0.87 | GRM5 (0.56) | GRM5CNR2 | |
| SCHEMBL992162 | 0.87 | GRM5 (0.56) | GRM5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563934-A1 | PREDICTIVE MARKERS USEFUL IN THE TREATMENT OF FRAGILE X SYNDROME (FXS) | Novartis AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| EP-2320892-A2 | COMBINATION PRODUCTS | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |