Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990845 | 1.00 | GRM5 (0.56) | GRM5GRM4HDAC6CNR2EGFR | |
| SCHEMBL992297 | 0.90 | GRM5 (0.58) | GRM5 | |
| SCHEMBL992298 | 0.89 | CNR2 (0.48) | GRM5CNR2 | |
| SCHEMBL990819 | 0.89 | GRM5 (0.46) | GRM5CNR2 | |
| SCHEMBL990196 | 0.89 | CNR2 (0.48) | GRM5CNR2 | |
| SCHEMBL990171 | 0.89 | GRM5 (0.46) | GRM5CNR2 | |
| 2-Picolinic Acid SCHEMBL3631655 | 0.88 | GRM5 (0.50) | GRM5 | |
| SCHEMBL990944 | 0.87 | GRM5 (0.58) | GRM5CNR2 | |
| SCHEMBL990821 | 0.87 | GRM5 (0.44) | GRM5 | |
| SCHEMBL1906015 | 0.87 | GRM5 (0.58) | GRM5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |