Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.39 |
| ▸ | MASP2 | O00187 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907780 | 0.91 | KLKB1 (0.45) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1905072 | 0.90 | NAMPT (0.46) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1903988 | 0.90 | NAMPT (0.46) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1901351 | 0.89 | KLKB1 (0.42) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1903937 | 0.89 | PSMB1 (0.48) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1901817 | 0.89 | KLKB1 (0.49) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1906377 | 0.89 | PSMB1 (0.48) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1901348 | 0.89 | KLKB1 (0.42) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1901814 | 0.89 | KLKB1 (0.49) | KLKB1PDPK1NAMPTPSMB1PSMB5 | |
| SCHEMBL1901660 | 0.88 | KLKB1 (0.42) | KLKB1PDPK1NAMPTPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |