Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.44 |
| ▸ | PRKCI | P41743 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18602197 | 0.85 | NUDT1 (0.52) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL99688 | 0.79 | NUDT1 (0.49) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL29540606 | 0.79 | ROCK1 (0.52) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL99400 | 0.79 | ROCK1 (0.52) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL12257978 | 0.76 | NUDT1 (0.56) | NUDT1CITROCK1PRKCICCNK | |
| Trifluoroacetic Acid SCHEMBL29540745 | 0.71 | ROCK1 (0.48) | NUDT1CITROCK1PRKCICCNK | |
| Trifluoroacetic Acid SCHEMBL5145042 | 0.71 | ROCK1 (0.48) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL98272 | 0.69 | ROCK1 (0.62) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL14494761 | 0.69 | NUDT1 (0.64) | NUDT1CITROCK1PRKCICCNK | |
| SCHEMBL29541527 | 0.68 | ROCK1 (0.63) | NUDT1CITROCK1PRKCICCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |