Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 5/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009648 | 0.86 | DAO (0.55) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL178310 | 0.84 | CHRM2 (0.55) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL77358 | 0.82 | CETP (0.59) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL1044620 | 0.82 | CHRM2 (0.57) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL92907 | 0.82 | CETP (0.55) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL7931524 | 0.82 | CETP (0.51) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL2094315 | 0.82 | CETP (0.51) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL8224420 | 0.82 | CETP (0.55) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL7118708 | 0.82 | CETP (0.51) | CETPCHRM2CHRM1CHRM3DAO | |
| SCHEMBL447002 | 0.82 | CETP (0.51) | CETPCHRM2CHRM1CHRM3DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |