SCHEMBL77358

SCHEMBL77358

FC(F)(F)Oc1cccc(CBr)c1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CETP P11597 8/20 0.59
CHRM2 P08172 1/20 0.50
CHRM1 P11229 1/20 0.50
CHRM3 P20309 1/20 0.50
DAO P14920 1/20 0.49
MAPK14 Q16539 1/20 0.46
TRPM8 Q7Z2W7 1/20 0.44
SLC6A4 P31645 1/20 0.43
CARM1 Q86X55 1/20 0.43
PRMT6 Q96LA8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30516108 1.00 CETP (0.59) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL4164702 0.93 CETP (0.56) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL30677435 0.85 CHRM2 (0.55) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL3119286 0.85 CHRM2 (0.55) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL5009648 0.84 DAO (0.55) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL3284271 0.84 CETP (0.51) CETP
SCHEMBL178310 0.82 CHRM2 (0.55) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL19062249 0.82 CETP (0.53) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL80141 0.82 CHRM2 (0.52) CETPCHRM2CHRM1CHRM3DAO
SCHEMBL2094315 0.81 CETP (0.51) CETPCHRM2CHRM1CHRM3DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 799 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114773330-B Butylphthalide-oxa/thiadiazole compound and preparation method and application thereof 贵州医科大学 2024-03-15 CN claimed
CN-114773330-A Butylphthalide-oxa/thiadiazole compound and preparation method and application thereof 贵州医科大学 2022-07-22 CN claimed
WO-2026099594-A1 THERAPEUTIC BIFUNCTIONAL AGENTS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2026-05-15 WO disclosed
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 US disclosed
EP-4692085-A2 PROSTAGLANDIN EP4 RECEPTOR ANTAGONIST COMPOUNDS Nxera Pharma UK Limited (GB) 2026-02-11 EP disclosed
EP-4041388-B1 PROSTAGLANDIN EP4 RECEPTOR ANTAGONIST COMPOUNDS NXERA PHARMA UK LTD (GB) 2025-11-26 EP disclosed
US-12421273-B2 Ectonucleotidase inhibitors and methods of use thereof ANTENGENE THERAPEUTICS LIMITED (CN) 2025-09-23 US disclosed
US-20250282783-A1 PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS Stablix, Inc. 2025-09-11 US disclosed
US-12410142-B2 Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof XIAMEN VIVOHEALTHS TECHNOLOGY CO., LTD. (CN) 2025-09-09 US disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
EP-4561561-A2 SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR Septerna, Inc. (US) 2025-06-04 EP disclosed
US-5824687-A BACTERICIDE, ANTIULCER AGENTS TREATING STOMACH OR INTESTINE CAUSED BY CAMPYLOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1998-10-20 US disclosed
WO-1997038665-A2 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1997-10-23 WO disclosed
US-4596880-A Pesticides BAYER AKTIENGESELLSCHAFT (DE) 1986-06-24 US disclosed
EP-0006978-B1 BENZYL ESTERS WITH FLUORINATED ETHER AND/OR THIOETHER GROUPS, THEIR PREPARATIONS AND THEIR USE AS INSECTICIDES; INTERMEDIATE PRODUCTS AND THEIR PREPARATIONS BAYER AG (DE) 1986-01-29 EP disclosed
US-4438275-A 2,2-DIFLUORO-BENZODIOXOLES BAYER AKTIENGESELLSCHAFT (DE) 1984-03-20 US disclosed
US-4411912-A Insecticidal isovaleric acid esters ZOECON CORPORATION (US) 1983-10-25 US disclosed
US-4310540-A PYRETHROID-LIKE COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1982-01-12 US disclosed
US-4243819-A Substituted amino acids ZOECON CORPORATION (US) 1981-01-06 US disclosed
EP-0006978-A2 Benzyl esters with fluorinated ether and/or thioether groups, their preparations and their use as insecticides; intermediate products and their preparations BAYER AG (DE) 1980-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 CETP 1683/4885CHRM2 128/4885CHRM1 76/4885
US-20250282783-A1 PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS USP28, USP25, USP24 CETP 3173/4885CHRM2 4753/4885CHRM1 4554/4885
US-12421273-B2 Ectonucleotidase inhibitors and methods of use thereof NT5E, ENTPD5, NT5C2 CETP 1855/4885CHRM2 1412/4885CHRM1 1381/4885
US-12410142-B2 Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof ALDOA, IDE, ACAT1 CETP 111/4885CHRM2 2734/4885CHRM1 3651/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 CETP 3592/4885CHRM2 136/4885CHRM1 58/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.