⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391663 | 1.00 | — | — | |
| SCHEMBL29398110 | 1.00 | — | — | |
| SCHEMBL338633 | 0.79 | — | — | |
| SCHEMBL10620493 | 0.79 | — | — | |
| SCHEMBL1367110 | 0.75 | — | — | |
| SCHEMBL1143136 | 0.75 | — | — | |
| SCHEMBL3576251 | 0.75 | — | — | |
| SCHEMBL12992242 | 0.75 | — | — | |
| SCHEMBL1186659 | 0.75 | — | — | |
| SCHEMBL31321833 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4401 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-222019488-U | Feeding device of 2, 4-dichloro-5-fluoropyrimidine ton bag | 上海康鹏科技股份有限公司 | 2024-11-19 | — | — | CN | claimed |
| CN-118767991-A | Catalyst, preparation method thereof and application of catalyst in cyclododecanone synthesis | 万华化学集团股份有限公司 | 2024-10-15 | — | — | CN | claimed |
| CN-221514411-U | 2, 4-Dichloro-5-fluoropyrimidine slicer | 上海康鹏科技股份有限公司 | 2024-08-13 | — | — | CN | claimed |
| CN-115636826-B | Preparation method of CDK inhibitor | 常州英诺升康生物医药科技有限公司 | 2024-06-25 | — | — | CN | claimed |
| WO-2023213211-A9 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2024-03-21 | — | — | WO | claimed |
| WO-2023213211-A1 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2023-11-09 | — | — | WO | claimed |
| CN-116514779-A | 2, 4-disubstituted-5-fluoropyrimidine derivative and preparation method and application thereof | 中南大学 | 2023-08-01 | — | — | CN | claimed |
| CN-116514724-A | Preparation method of 2, 4-dichloro-5-fluoropyrimidine | 上海康鹏科技股份有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-110078672-B | Preparation method of high-purity 2, 4-dichloro-5-fluoropyrimidine | 启东东岳药业有限公司 | 2023-02-24 | — | — | CN | claimed |
| CN-115636826-A | Preparation method of CDK inhibitor | 常州英诺升康生物医药科技有限公司 | 2023-01-24 | — | — | CN | claimed |
| WO-2011045807-A2 | A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL | NEULAND LABORATORIES LTD. (IN) | 2011-04-21 | — | — | WO | claimed |
| US-7803939-B2 | N2,N4-bis(4-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine; inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators; Syk kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | claimed |
| US-7655797-B2 | reacting a aminobenzoxazne or aminobenzothiazine or aminobenzodithiazine compounds wtih 2,4-dichloro-5-fluoropyrimidine to form 2,4-pyrimidinediamne compound; used to inhibit IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators; antiinflammatory agent, antiallergen | RIGEL PHARMACEUTICALS, INC. (US) | 2010-02-02 | — | — | US | claimed |
| US-20090171085-A1 | N2,N4-bis(4-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine; inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators; Syk kinase inhibitors | RIGEL PHARMACEUTICALS, INC. | 2009-07-02 | — | — | US | claimed |
| US-20090082567-A1 | reacting a aminobenzoxazne or aminobenzothiazine or aminobenzodithiazine compounds wtih 2,4-dichloro-5-fluoropyrimidine to form 2,4-pyrimidinediamne compound; used to inhibit IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators; antiinflammatory agent, antiallergen | RIGEL PHARMACEUTICALS, INC. | 2009-03-26 | — | — | US | claimed |
| EP-0587839-A4 | PROCESS FOR THE PREPARATION OF 2-ALKYLTHIO-4-HYDRAZINO-5-FLUOROPYRIMIDINES. | DOWELANCO (US) | 1995-04-05 | — | — | EP | claimed |
| EP-0587839-A1 | PROCESS FOR THE PREPARATION OF 2-ALKYLTHIO-4-HYDRAZINO-5-FLUOROPYRIMIDINES | DOWELANCO (US) | 1994-03-23 | — | — | EP | claimed |
| WO-1993018011-A1 | PROCESS FOR THE PREPARATION OF 2-ALKYLTHIO-4-HYDRAZINO-5-FLUOROPYRIMIDINES | DOWELANCO (US) | 1993-09-16 | — | — | WO | claimed |
| US-5155221-A | Process for the preparation of 2-alkylthio-4-hydrazino-5-fluoropyrimidines | DOWELANCO (US) | 1992-10-13 | — | — | US | claimed |
| US-4092313-A | FROM 2,4-DICHLORO-5-FLUOROPYRIMIDINE AND AN ALCOHOLATE OR A PHENOLATE TO PRODUCE 2,4-DISUBSTITUTED DERIVATIVE, HYDROLYSIS | TAISHO PHARMACEUTICAL COMPANY LIMITED (JA) | 1978-05-30 | — | — | US | claimed |