Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | MASP2 | O00187 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.38 |
| ▸ | MMP2 | P08253 | 5/20 | 0.38 |
| ▸ | MMP3 | P08254 | 5/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | FURIN | P09958 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906627 | 1.00 | F2 (0.40) | F2PRSS1MASP2EPHX2MMP1 | |
| SCHEMBL1431923 | 0.87 | PSMB10 (0.40) | F2MASP2F10FURIN | |
| SCHEMBL1431917 | 0.87 | PSMB10 (0.40) | F2MASP2F10FURIN | |
| SCHEMBL1903263 | 0.86 | MASP2 (0.40) | F2PRSS1MASP2F10FURIN | |
| SCHEMBL1903269 | 0.86 | MASP2 (0.40) | F2PRSS1MASP2F10FURIN | |
| SCHEMBL1908448 | 0.86 | PSMB5 (0.41) | F2PRSS1MASP2MMP1 | |
| SCHEMBL1908449 | 0.86 | PSMB5 (0.41) | F2PRSS1MASP2MMP1 | |
| SCHEMBL1908452 | 0.86 | PSMB5 (0.41) | F2PRSS1MASP2MMP1 | |
| SCHEMBL1907759 | 0.85 | PSMB10 (0.41) | MASP2FURIN | |
| SCHEMBL1907760 | 0.85 | PSMB10 (0.41) | MASP2FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |