Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260079 | 0.74 | MAPT (0.47) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL2645820 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL317052 | 0.73 | CYP19A1 (0.50) | ALDH1A1CYP1A2SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL23674896 | 0.71 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL28286005 | 0.71 | CYP19A1 (0.54) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL1851250 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL12090074 | 0.70 | CREBBP (0.53) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL15653177 | 0.69 | DAO (0.46) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL6938242 | 0.69 | CREBBP (0.56) | ALDH1A1KMT2AMEN1PKMCREBBP | |
| SCHEMBL28402722 | 0.69 | CREBBP (0.52) | ALDH1A1KMT2AMEN1PKMCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382257-B2 | Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors | GENENTECH, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2909206-A1 | SERINE/THREONINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| US-20150218176-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2015-08-06 | — | — | US | disclosed |
| WO-2014060395-A1 | SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| US-8455477-B2 | Therapeutic compounds | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110207711-A1 | Therapeutic Compounds | MSD K.K. (JP) | 2011-08-25 | — | — | US | disclosed |
| EP-2320907-A1 | THERAPEUTIC COMPOUNDS | Merck & Co., Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010017047-A1 | THERAPEUTIC COMPOUNDS | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207711-A1 | Therapeutic Compounds | WEE2, MARK3, WEE1 | ALDH1A1 4287/4885KMT2A 2181/4885MEN1 1277/4885 |
| US-20150218176-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K2, MAP3K20 | ALDH1A1 2724/4885KMT2A 2058/4885MEN1 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.