Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322343 | 0.84 | NOTUM (0.50) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL15358151 | 0.83 | NOTUM (0.49) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL15358059 | 0.83 | NOTUM (0.49) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL10322791 | 0.83 | NOTUM (0.49) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL3555140 | 0.82 | CA1 (0.54) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL13125475 | 0.81 | NPFFR2 (0.42) | NOTUMPDK1LMNAGAAMAPT | |
| SCHEMBL22400332 | 0.81 | NOTUM (0.69) | NOTUMPDK2CA12CA1CA2 | |
| SCHEMBL25677846 | 0.81 | NOTUM (0.50) | NOTUMPDK2CA12CA1CA2 | |
| SCHEMBL29528597 | 0.81 | NOTUM (0.69) | NOTUMPDK2CA12CA1CA2 | |
| SCHEMBL15357970 | 0.80 | NOTUM (0.47) | NOTUMPDK2PDK1PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2842939-B1 | BENZAMIDE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-05-30 | — | — | EP | disclosed |
| US-9695118-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2017-07-04 | — | — | US | disclosed |