Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.43 |
| ▸ | BRD2 | P25440 | 11/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 11/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907809 | 0.86 | BRD4 (0.48) | BRD4BRD2BRD3FFAR1CYP3A4 | |
| SCHEMBL13732133 | 0.82 | BRD4 (0.47) | BRD4BRD2BRD3FFAR1CYP3A4 | |
| SCHEMBL13732130 | 0.81 | BRD4 (0.46) | BRD4BRD2BRD3FFAR1CYP3A4 | |
| SCHEMBL15314278 | 0.76 | BRD4 (0.50) | BRD4BRD2BRD3FFAR1NR3C1 | |
| SCHEMBL1905062 | 0.74 | DHODH (0.49) | BRD4BRD2BRD3FFAR1 | |
| SCHEMBL1907803 | 0.73 | BRD4 (0.48) | BRD4BRD2BRD3FFAR1NR3C1 | |
| SCHEMBL1906132 | 0.73 | BRD4 (0.48) | BRD4BRD2BRD3FFAR1NR3C1 | |
| SCHEMBL24398567 | 0.73 | POLB (0.52) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL12095422 | 0.72 | FFAR1 (0.44) | BRD4BRD2BRD3FFAR1NR3C1 | |
| SCHEMBL12677343 | 0.71 | DHODH (0.44) | BRD4BRD2BRD3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011054846-A1 | IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |