Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.48 |
| ▸ | BRD2 | P25440 | 8/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906132 | 1.00 | BRD4 (0.48) | BRD4BRD2BRD3NR3C1FFAR1 | |
| SCHEMBL16896898 | 0.88 | BRD4 (0.48) | BRD4BRD2BRD3NR3C1ATAD2 | |
| SCHEMBL17467705 | 0.87 | MAP4K4 (0.40) | BRD4BRD2BRD3NR3C1ATAD2 | |
| SCHEMBL15314278 | 0.84 | BRD4 (0.50) | BRD4BRD2BRD3NR3C1FFAR1 | |
| SCHEMBL29619075 | 0.81 | BRD4 (0.45) | BRD4BRD2BRD3FFAR1ATAD2 | |
| SCHEMBL11980660 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3ATAD2 | |
| SCHEMBL1907809 | 0.81 | BRD4 (0.48) | BRD4BRD2BRD3NR3C1FFAR1 | |
| SCHEMBL16619524 | 0.80 | ATAD2 (0.46) | BRD4BRD2BRD3FFAR1ATAD2 | |
| SCHEMBL13732133 | 0.79 | BRD4 (0.47) | BRD4BRD2BRD3NR3C1FFAR1 | |
| SCHEMBL19422785 | 0.79 | BRD4 (0.50) | BRD4BRD2BRD3NR3C1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699573-B1 | 7-(3,5-DIMETHYL-4-ISOXAZOLYL)-8-(METHYLOXY)-1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES | GLAXOSMITHKLINE LLC (US) | 2017-05-31 | — | — | EP | disclosed |
| US-8846709-B2 | 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1H-imidazo[4,5-C]quinoline derivatives | GLAXOSMITHKLINE LLC (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2699573-A2 | 7-(3,5-DIMETHYL-4-ISOXAZOLYL)-8-(METHYLOXY)-1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES | Glaxosmithkline LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-20140045834-A1 | 7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives | GLAXOSMITHKLINE LLC (US) | 2014-02-13 | — | — | US | disclosed |
| EP-2496576-B1 | IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-12-18 | — | — | EP | disclosed |
| US-8557984-B2 | Imidazo [4, 5-C] quinoline derivatives as bromodomain inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-10-15 | — | — | US | disclosed |
| WO-2012143416-A2 | NOVEL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-10-26 | — | — | WO | disclosed |
| US-20120232074-A1 | Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors | GLAXOSMITHKLINE LLC | 2012-09-13 | — | — | US | disclosed |
| EP-2496576-A1 | IMIDAZO [4, 5-C]QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054846-A1 | IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045834-A1 | 7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, UGT2B7, UGT1A7 | BRD4 5/4885BRD2 475/4885BRD3 96/4885 |
| US-20120232074-A1 | Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors | BRD4, BRD3, BRPF3 | BRD4 1/4885BRD2 5/4885BRD3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.