Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.60 |
| ▸ | TNF | P01375 | 3/20 | 0.60 |
| ▸ | IL1B | P01584 | 3/20 | 0.60 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23226143 | 0.86 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL20612264 | 0.86 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL5138324 | 0.82 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22873882 | 0.80 | CRBN (0.51) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL23226068 | 0.79 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25137979 | 0.78 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19582932 | 0.78 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25138060 | 0.76 | CRBN (0.51) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL13700365 | 0.75 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| Pomalidomide SCHEMBL563317 | 0.75 | CRBN (1.00) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496568-B1 | POLYMORPH OF 3-(SUBSTITUTEDDIHYDROISOINDOLINONE-2-YL)-2,6-DIOXOPIPERIDINE, AND PHARMACEUTICAL COMPOSITIONS THEREOF | NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD (CN) | 2017-04-26 | — | — | EP | claimed |
| EP-2504703-A1 | IMMUNOMODULATORY COMPOUNDS FOR THE RESTORATION OF VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS | Celgene Corporation (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011066351-A1 | IMMUNOMODULATORY COMPOUNDS FOR THE RESTORATION OF VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS | CELGENE CORPORATION (US) | 2011-06-03 | — | — | WO | disclosed |
| EP-2316455-A1 | Pharmaceutical compositions for treating cancer | CELGENE CORPORATION (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20090148853-A1 | BIOMARKERS FOR PREDICTING THE SENSITIVITY OF CELLS TO IMMUNOMODULATORY COMPOUNDS DURING TREATMENT OF NON-HODGKIN'S LYMPHOMA | CELGENE CORPORATION | 2009-06-11 | — | — | US | disclosed |