Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 10/20 | 0.49 |
| ▸ | KLK1 | P06870 | 4/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.42 |
| ▸ | FCER2 | P06734 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904109 | 0.92 | NAMPT (0.44) | KLKB1KLK1FPR2MASP2NAMPT | |
| SCHEMBL1904105 | 0.92 | NAMPT (0.44) | KLKB1KLK1FPR2MASP2NAMPT | |
| SCHEMBL1901841 | 0.91 | CTSB (0.48) | KLKB1KLK1MASP2 | |
| SCHEMBL1901838 | 0.91 | CTSB (0.48) | KLKB1KLK1MASP2 | |
| SCHEMBL1431700 | 0.91 | KLKB1 (0.49) | KLKB1KLK1FPR2MASP2FCER2 | |
| SCHEMBL3153048 | 0.91 | KLKB1 (0.49) | KLKB1KLK1FPR2MASP2FCER2 | |
| SCHEMBL1906052 | 0.90 | KLKB1 (0.47) | KLKB1KLK1MASP2FCER2MMP1 | |
| SCHEMBL1902345 | 0.90 | KLKB1 (0.47) | KLKB1KLK1MASP2FCER2MMP1 | |
| SCHEMBL3137935 | 0.90 | KLKB1 (0.53) | KLKB1KLK1FPR2MASP2FCER2 | |
| SCHEMBL3137925 | 0.90 | KLKB1 (0.53) | KLKB1KLK1FPR2MASP2FCER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |