Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.66 |
| ▸ | RECQL | P46063 | 3/20 | 0.66 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.66 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079842 | 0.90 | PDE4D (0.63) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19079668 | 0.90 | TSHR (0.68) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19079699 | 0.90 | PDE4D (0.63) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19079866 | 0.90 | PDE4D (0.63) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19079847 | 0.87 | CREBBP (0.56) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL14478791 | 0.81 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL13856555 | 0.80 | POLB (1.00) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19090635 | 0.79 | TSHR (0.67) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19090740 | 0.79 | PDE4D (0.62) | ALDH1A1SMN1; SMN2POLBTDP1RECQL | |
| SCHEMBL19079783 | 0.76 | PDE4D (0.80) | ALDH1A1SMN1; SMN2POLBTDP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | VANDERBILT UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | PDE4A, PDE4B, PDE7A | ALDH1A1 1503/4885SMN1; SMN2 4025/4885POLB 2192/4885 |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | ALDH1A1 1503/4885SMN1; SMN2 4025/4885POLB 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.