SCHEMBL1908012

SCHEMBL1908012

CCSc1nnc(-n2sc3ccccc3c2=O)s1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT2B Q92831 6/20 0.54
KAT2A Q92830 5/20 0.54
EP300 Q09472 4/20 0.49
MPI P34949 11/20 0.48
G6PD P11413 7/20 0.48
ALDH1A1 P00352 6/20 0.48
MAPT P10636 6/20 0.48
KDM4E B2RXH2 5/20 0.48
TDP1 Q9NUW8 5/20 0.48
PKM P14618 4/20 0.48
GAA P10253 1/20 0.48
PHOSPHO1 Q8TCT1 8/20 0.46
PMM2 O15305 7/20 0.46
HPGD P15428 4/20 0.46
ALOX12 P18054 4/20 0.46
APOBEC3G Q9HC16 4/20 0.46
CASP3 P42574 3/20 0.46
NPSR1 Q6W5P4 2/20 0.46
HSP90AA1 P07900 1/20 0.46
TP53 P04637 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1904049 0.85 KAT2B (0.55) KAT2BKAT2AEP300MPIG6PD
SCHEMBL1906226 0.75 MPI (0.55) KAT2BKAT2AEP300MPIG6PD
SCHEMBL1905901 0.73 KAT2B (0.56) KAT2BKAT2AEP300MPIG6PD
SCHEMBL1896492 0.71 KAT2B (0.65) KAT2BKAT2AEP300MPIG6PD
SCHEMBL21687131 0.71 KAT2B (1.00) KAT2BKAT2AEP300MPIG6PD
SCHEMBL1903519 0.69 KAT2B (0.51) KAT2BKAT2AEP300MPIG6PD
SCHEMBL21846491 0.68 KAT2A (0.47) KAT2BKAT2AEP300MPIG6PD
SCHEMBL21846446 0.68 KAT2B (0.50) KAT2BKAT2AEP300MPIG6PD
SCHEMBL1907874 0.68 MPI (0.60) KAT2BKAT2AEP300MPIG6PD
SCHEMBL8371733 0.67 G6PD (0.64) KAT2BKAT2AMPIG6PDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3732180-A1 COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID-SPECIFIC ANTIVIRAL AGENTS Emory University (US) 2020-11-04 EP claimed
WO-2011062864-A2 INHIBITORS OF NOX ENZYMES AND METHODS OF USE THEREOF EMORY UNIVERSITY (US) 2011-05-26 WO claimed
EP-3980400-B1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS UNIV EMORY (US) 2025-08-06 EP disclosed
US-12268723-B2 Peptidomimetics for the treatment of coronavirus and picorna virus infections EMORY UNIVERSITY (US) 2025-04-08 US disclosed
CN-117769427-A Modified nucleosides and nucleotide analogues as antiviral agents for coronaviruses and other viruses 埃默里大学 2024-03-26 CN disclosed
EP-4319764-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
EP-4319763-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES Emory University (US) 2024-02-14 EP disclosed
EP-4319762-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
WO-2022217154-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217155-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217153-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022170396-A1 AGENTS AND METHODS FOR THERAPY AND PROPHYLAXIS ViraLok Therapeutics Pty Ltd (AU) 2022-08-18 WO disclosed
EP-3980400-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS Emory University (US) 2022-04-13 EP disclosed
WO-2020247665-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS EMORY UNIVERSITY (US) 2020-12-10 WO disclosed
EP-3732180-A1 COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID-SPECIFIC ANTIVIRAL AGENTS Emory University (US) 2020-11-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12268723-B2 Peptidomimetics for the treatment of coronavirus and picorna virus infections ACE2, SARS1, HAVCR2 KAT2B 4726/4885KAT2A 4465/4885EP300 3526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.