Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 11/20 | 0.53 |
| ▸ | ATF1 | P18846 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19064507 | 0.88 | P2RX1 (0.55) | P2RX1P2RX4P2RX7TMPRSS4PTGES | |
| SCHEMBL29577337 | 0.88 | P2RX1 (0.55) | P2RX1P2RX4P2RX7TMPRSS4PTGES | |
| SCHEMBL23512207 | 0.80 | P2RX1 (0.56) | P2RX1P2RX4P2RX7TMPRSS4ATF1 | |
| SCHEMBL21645628 | 0.78 | PTGES (0.54) | TMPRSS4PTGESATF1NFKB1NPC1 | |
| SCHEMBL30899219 | 0.78 | PTGES (0.54) | TMPRSS4PTGESATF1NFKB1NPC1 | |
| SCHEMBL30899214 | 0.77 | PTGES (0.52) | TMPRSS4PTGESDHODH | |
| SCHEMBL21645366 | 0.77 | PTGES (0.52) | TMPRSS4PTGESDHODH | |
| SCHEMBL21645373 | 0.77 | MAPT (0.47) | P2RX1P2RX4P2RX7PTGESNFKB1 | |
| SCHEMBL30899218 | 0.77 | MAPT (0.47) | P2RX1P2RX4P2RX7PTGESNFKB1 | |
| SCHEMBL23512180 | 0.74 | P2RX1 (0.55) | P2RX1P2RX4P2RX7TMPRSS4ATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190675-A1 | CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE | DUKE UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190675-A1 | CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE | CD274, PDCD1, PDCD1LG2 | P2RX1 1425/4885P2RX4 1249/4885P2RX7 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.