Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13404648 | 0.81 | CYP1A2 (0.47) | HRH3KCNH2CYP2D6MGLL | |
| SCHEMBL17244903 | 0.79 | HRH3 (0.43) | HRH3KCNH2CYP2D6MGLLCHRNA7 | |
| SCHEMBL24444266 | 0.78 | HRH3 (0.42) | HRH3KCNH2CYP2D6MGLL | |
| SCHEMBL681679 | 0.78 | ALDH1A1 (0.56) | MGLL | |
| SCHEMBL2737190 | 0.76 | HRH3 (0.58) | HRH3KCNH2CYP2D6 | |
| SCHEMBL28216008 | 0.76 | CYP1A2 (0.52) | HRH3 | |
| SCHEMBL3967519 | 0.76 | HRH3 (0.47) | HRH3KCNH2CYP2D6CHRNA7 | |
| SCHEMBL15934198 | 0.76 | CYP1A2 (0.52) | MGLL | |
| SCHEMBL26680011 | 0.75 | HRH3 (0.66) | HRH3KCNH2CYP2D6CHRNA7 | |
| SCHEMBL13503648 | 0.75 | KIT (0.44) | HRH3KCNH2CYP2D6MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190708-A1 | PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2017-07-06 | — | — | US | disclosed |
| US-20170190708-A1 | PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190708-A1 | PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT | TYMP, ZC3HAV1, TYMS | HRH3 1844/4885KCNH2 1977/4885CYP2D6 728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.