Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 1.00 |
| ▸ | CD44 | P16070 | 2/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29360217 | 1.00 | PNMT (1.00) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28236302 | 1.00 | PNMT (1.00) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11213530 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL20524019 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL987515 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL4243903 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL5411332 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL2082936 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL6635293 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A | |
| SCHEMBL11838922 | 0.97 | PNMT (0.95) | PNMTCD44MAOBHTR2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 41762 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146035-A1 | FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS | DONG-A ST CO., LTD. (KR) | 2026-05-28 | — | — | US | claimed |
| CN-116867788-B | 4-Aminoquinazoline compounds | ASTELLAS PHARMA INC. (JP) | 2026-05-26 | — | — | CN | claimed |
| WO-2026097209-A1 | USE OF TETRAHYDROISOQUINOLINE COMPOUND IN PREPARATION OF ANTI-LEUKEMIA DRUG | 中新生物医药(深圳)有限公司 | 2026-05-15 | — | — | WO | claimed |
| WO-2026097783-A1 | USE OF TETRAHYDROISOQUINOLINE COMPOUND IN PREPARATION OF ANTI-LEUKEMIA DRUG | 中新生物医药(深圳)有限公司 | 2026-05-15 | — | — | WO | claimed |
| EP-4741375-A1 | SULFONYLUREA DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | Qubit Pharmaceuticals (FR) | 2026-05-13 | — | — | EP | claimed |
| CN-122005558-A | Compound serving as AKR1C3 inhibitor as well as preparation method and application thereof | 广州医科大学 | 2026-05-12 | — | — | CN | claimed |
| EP-4722187-A1 | BUILDING BLOCK FOR TRIFLUOROALKYLATION AND TRIFLUOROALKYLATION METHOD USING SAME | Seoul National University Hospital (KR) | 2026-04-08 | — | — | EP | claimed |
| CN-121574041-A | Dual-band bianthracene photocatalyst and preparation method and application thereof | 江西初源新材料有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20260048156-A1 | FAP-TARGETING PHARMACEUTICAL PRODUCT FOR THERAPY AND DIAGNOSIS OF CANCERS | Atoms for Cure GmbH (DE) | 2026-02-19 | — | — | US | claimed |
| EP-4695234-A1 | PYRIDO[3,4-D]PYRIMIDINONE AND PYRIMIDINE ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND USES THEREOF | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. (CN) | 2026-02-18 | — | — | EP | claimed |
| US-4066764-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-01-03 | — | — | US | claimed |
| US-4062961-A | SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES | SMITHKLINE CORPORATION (US) | 1977-12-13 | — | — | US | claimed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | claimed |
| US-4049655-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | claimed |
| US-4029650-A | VASODILATORS | DELALANDE S. A. (FR) | 1977-06-14 | — | — | US | claimed |
| US-4021400-A | SECONDARY AMINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-05-03 | — | — | US | claimed |
| US-3988339-A | 7 OR 8-SUBSTITUTED 1,2,3,4-TETRAHYDRO-ISOQUINOLINE | SMITHKLINE CORPORATION (US) | 1976-10-26 | — | — | US | claimed |
| US-3980655-A | Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | claimed |
| US-3978063-A | 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1976-08-31 | — | — | US | claimed |
| US-3963725-A | 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1976-06-15 | — | — | US | claimed |