Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085337 | 0.91 | BRS3 (0.49) | BRS3NPC1RAB9AMRGPRX4HDAC8 | |
| SCHEMBL13477501 | 0.89 | NPC1 (0.48) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19085191 | 0.85 | BRS3 (0.47) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20621045 | 0.84 | BRS3 (0.44) | BRS3NPC1RAB9AHDAC8SMN1; SMN2 | |
| SCHEMBL20620524 | 0.84 | BRS3 (0.44) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19085342 | 0.83 | BRS3 (0.56) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13477458 | 0.82 | BRS3 (0.43) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20620617 | 0.81 | BRS3 (0.44) | BRS3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20620620 | 0.81 | BRS3 (0.48) | BRS3NPC1RAB9AMRGPRX4SMN1; SMN2 | |
| SCHEMBL13477546 | 0.81 | BRS3 (0.41) | BRS3NPC1RAB9AHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | SELDAR PHARMA INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | BRS3 1/4885NPC1 2242/4885RAB9A 404/4885 |
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | BRS3, BDKRB2, NTSR2 | BRS3 1/4885NPC1 2242/4885RAB9A 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.