SCHEMBL19086010 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	7/20	0.36

▸	WDR77	Q9BQA1	7/20	0.36

▸	USP2	O75604	1/20	0.35

▸	KDM1A	O60341	5/20	0.34

▸	HCRTR2	O43614	4/20	0.34

▸	HDAC6	Q9UBN7	5/20	0.33

▸	ALDH1A1	P00352	2/20	0.33

▸	HCRTR1	O43613	2/20	0.33

▸	KDM4E	B2RXH2	1/20	0.33

▸	LMNA	P02545	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086261	0.89	PRMT5 (0.41)	PRMT5WDR77KDM1AHDAC6ALDH1A1
SCHEMBL19085975	0.84	PRMT5 (0.37)	PRMT5WDR77USP2KDM1AHCRTR2
SCHEMBL19086242	0.79	KDM1A (0.41)	PRMT5WDR77KDM1AHCRTR2HDAC6
SCHEMBL19087006	0.79	PRMT5 (0.38)	PRMT5WDR77KDM1AHCRTR2HDAC6
SCHEMBL19086008	0.78	KDM1A (0.42)	PRMT5WDR77KDM1AHDAC6ALDH1A1
SCHEMBL19086211	0.77	PRMT5 (0.42)	PRMT5WDR77KDM1AHCRTR2ALDH1A1
SCHEMBL19087007	0.76	PRMT5 (0.38)	PRMT5WDR77HDAC6
SCHEMBL19086011	0.76	KDM1A (0.43)	PRMT5WDR77KDM1AHCRTR2HDAC6
SCHEMBL19085992	0.76	PRMT5 (0.40)	PRMT5WDR77
SCHEMBL19085997	0.76	PRMT5 (0.40)	PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed