Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085997 | 0.89 | PRMT5 (0.40) | PRMT5WDR77ROCK1ROCK2 | |
| SCHEMBL19085992 | 0.89 | PRMT5 (0.40) | PRMT5WDR77ROCK1ROCK2 | |
| SCHEMBL19085986 | 0.85 | PRMT5 (0.39) | PRMT5WDR77HCRTR2ROCK1HCRTR1 | |
| SCHEMBL19085988 | 0.84 | HCRTR2 (0.40) | PRMT5WDR77HCRTR2HCRTR1 | |
| SCHEMBL19086010 | 0.84 | PRMT5 (0.36) | PRMT5WDR77USP2HCRTR2KDM1A | |
| SCHEMBL19085979 | 0.82 | MAOB (0.41) | PRMT5WDR77ROCK1KDM1AHDAC6 | |
| SCHEMBL19086041 | 0.81 | ROCK2 (0.40) | PRMT5WDR77USP2HCRTR2ROCK1 | |
| SCHEMBL19085982 | 0.80 | KDM4E (0.39) | PRMT5WDR77HCRTR2ROCK1KDM1A | |
| SCHEMBL19085980 | 0.80 | PRMT5 (0.40) | PRMT5WDR77ROCK1HDAC6ROCK2 | |
| SCHEMBL19086260 | 0.80 | METTL3 (0.38) | PRMT5WDR77ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |