SCHEMBL19086538

SCHEMBL19086538

COC(=O)c1c(O)c2ccc(Oc3ccccc3)cc2n(CCC2CC2)c1=O

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 19/20 0.77
CNR2 P34972 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086601 0.90 HIF1A (0.76) HIF1ACNR2
SCHEMBL17578541 0.87 HIF1A (1.00) HIF1A
SCHEMBL23953026 0.86 HIF1A (0.67) HIF1ACNR2
SCHEMBL19086526 0.83 HIF1A (0.53) HIF1ACNR2
SCHEMBL19086529 0.82 HIF1A (0.71) HIF1A
SCHEMBL19113752 0.77 HIF1A (0.79) HIF1A
SCHEMBL17578427 0.77 HIF1A (1.00) HIF1A
SCHEMBL19113791 0.77 HIF1A (0.70) HIF1A
SCHEMBL19086664 0.76 HIF1A (0.71) HIF1A
SCHEMBL19086616 0.75 HIF1A (0.62) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3190104-B1 QUINOLINONE COMPOUND AND USE THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2021-10-27 EP disclosed
US-10065928-B2 Quinolinone compound and use thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2018-09-04 US disclosed
US-20170247332-A1 QUINOLINONE COMPOUND AND USE THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-08-31 US disclosed
EP-3190104-A1 QUINOLINONE COMPOUND AND USE THEREOF Sunshine Lake Pharma Co., Ltd. (CN) 2017-07-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170247332-A1 QUINOLINONE COMPOUND AND USE THEREOF HIF1AN, HIF1A, EGLN2 HIF1A 2/4885CNR2 802/4885
US-10065928-B2 Quinolinone compound and use thereof HIF1AN, HIF1A, EGLN2 HIF1A 2/4885CNR2 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.