Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17578433 | 0.90 | HIF1A (0.72) | HIF1AL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL19086545 | 0.83 | HIF1A (0.52) | HIF1AL3MBTL1MEN1KMT2ANLRP3 | |
| SCHEMBL23953030 | 0.81 | HIF1A (0.48) | HIF1AL3MBTL1MEN1KMT2ANLRP3 | |
| SCHEMBL17578572 | 0.75 | HIF1A (1.00) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL19086553 | 0.71 | HPGDS (0.46) | MEN1KMT2AGAAKDM4E | |
| SCHEMBL2383791 | 0.70 | HIF1A (0.72) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17578567 | 0.69 | HIF1A (0.67) | HIF1AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2382524 | 0.69 | HIF1A (0.61) | HIF1AEGLN1 | |
| SCHEMBL2399702 | 0.69 | MEN1 (0.77) | HIF1AL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL2383420 | 0.69 | HIF1A (0.69) | HIF1AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190104-B1 | QUINOLINONE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2021-10-27 | — | — | EP | disclosed |
| EP-3190104-A1 | QUINOLINONE COMPOUND AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |