Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908720 | 0.89 | USP30 (0.48) | MAPK1USP30EPHX2ATMCTSL | |
| SCHEMBL12086274 | 0.82 | USP30 (0.50) | USP30EPHX2CTSLCTSBCTSS | |
| SCHEMBL1908734 | 0.81 | MEN1 (0.51) | MAPK1EPHX2MEN1KMT2APAK1 | |
| SCHEMBL1911231 | 0.76 | EPHX2 (0.62) | USP30EPHX2CTSLCTSBCTSS | |
| SCHEMBL354641 | 0.76 | EPHX2 (0.66) | EPHX2CTSLCTSBCTSSCTSC | |
| SCHEMBL359333 | 0.76 | EPHX2 (0.66) | EPHX2CTSLCTSBCTSSCTSC | |
| SCHEMBL358834 | 0.76 | EPHX2 (0.66) | EPHX2CTSLCTSBCTSSCTSC | |
| SCHEMBL24381758 | 0.75 | MEN1 (0.67) | USP30EPHX2CTSLCTSBCTSS | |
| SCHEMBL1908655 | 0.75 | EPHX1 (0.61) | MAPK1USP30EPHX2CTSLCTSB | |
| SCHEMBL356730 | 0.75 | CTSL (0.65) | USP30EPHX2CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114877-B2 | Antiinflammatory agnets; chronic obstructive pulmonary diseases | NOVARTIS AG (CH) | 2012-02-14 | — | — | US | disclosed |