Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | F13A1 | P00488 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15359146 | 0.84 | ESRRG (0.54) | ESRRGGFERKDM4EF13A1SMN1; SMN2 | |
| SCHEMBL25683773 | 0.82 | NPC1 (0.53) | KDM4EF13A1SMN1; SMN2LMNACA12 | |
| SCHEMBL13930810 | 0.82 | KDM4E (0.47) | KDM4EF13A1SMN1; SMN2HIF1ALMNA | |
| SCHEMBL2715966 | 0.81 | KDM4E (0.70) | ESRRGGFERKDM4EF13A1SMN1; SMN2 | |
| SCHEMBL6307134 | 0.80 | NPC1 (0.59) | SMN1; SMN2IDO1LMNACA12CA1 | |
| Water SCHEMBL17767324 | 0.78 | NPC1 (0.57) | SMN1; SMN2IDO1LMNACA12CA1 | |
| SCHEMBL26709576 | 0.76 | ESRRG (0.57) | ESRRGGFERKDM4EF13A1SMN1; SMN2 | |
| SCHEMBL15940162 | 0.76 | ESRRG (0.57) | ESRRGGFERKDM4EF13A1SMN1; SMN2 | |
| SCHEMBL6679010 | 0.74 | ST14 (0.50) | ESRRGGFERKDM4EF13A1MAOB | |
| SCHEMBL625333 | 0.74 | ESRRG (0.55) | ESRRGGFERKDM4EF13A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041842-B1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2017114864-A1 | METHOD FOR PREPARING ACYLATED CROSSLINKED GLYCOSAMINOGLYCANS | GALDERMA S.A. (CH) | 2017-07-06 | — | — | WO | disclosed |