Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24251692 | 0.89 | EGFR (0.69) | EGFRALKKCNH2EML4 | |
| SCHEMBL17857068 | 0.87 | EGFR (0.69) | EGFRALKKCNH2EML4 | |
| SCHEMBL19440571 | 0.86 | EGFR (0.69) | EGFRALKKCNH2EML4 | |
| SCHEMBL19089663 | 0.85 | EGFR (0.82) | EGFRALKKCNH2EML4 | |
| SCHEMBL17373148 | 0.85 | EGFR (0.67) | EGFRALKKCNH2EML4 | |
| SCHEMBL17683089 | 0.85 | EGFR (0.77) | EGFRALKEML4 | |
| SCHEMBL20655995 | 0.85 | EGFR (0.77) | EGFRALKKCNH2EML4 | |
| SCHEMBL23937949 | 0.84 | EGFR (0.66) | EGFRALKKCNH2EML4 | |
| SCHEMBL26474195 | 0.84 | EGFR (0.65) | EGFRALKKCNH2EML4 | |
| SCHEMBL20892583 | 0.84 | EGFR (0.70) | EGFRALKKCNH2EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205650-B1 | EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) | 2021-08-04 | — | — | EP | disclosed |
| WO-2017114500-A1 | ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY | 恩瑞生物医药科技（上海）有限公司 | 2017-07-06 | — | — | WO | disclosed |