Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | CDK11B | P21127 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.40 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19089467 | 0.92 | KDR (0.44) | MAPK8MAPK9MAPK10KDREGFR | |
| SCHEMBL19089682 | 0.89 | ROCK1 (0.51) | MAPK8MAPK9MAPK10KDREGFR | |
| SCHEMBL19089608 | 0.88 | EGFR (0.50) | MAPK8MAPK9MAPK10KDREGFR | |
| Phenylmethanesulfonic Acid SCHEMBL35210294 | 0.85 | KDR (0.42) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL19337070 | 0.84 | EGFR (0.43) | MKNK1KDREGFRROCK1 | |
| SCHEMBL30930115 | 0.84 | KDR (0.43) | MAPK8MAPK9MAPK10MKNK1KDR | |
| SCHEMBL18586191 | 0.84 | KDR (0.43) | MAPK8MAPK9MAPK10MKNK1KDR | |
| SCHEMBL20637691 | 0.83 | KDR (0.41) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL19089534 | 0.81 | CDC7 (0.44) | KDREGFRROCK1 | |
| SCHEMBL35210303 | 0.81 | CDC7 (0.44) | KDREGFRROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114500-A1 | ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY | 恩瑞生物医药科技（上海）有限公司 | 2017-07-06 | — | — | WO | disclosed |