Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090405 | 0.86 | HTT (0.42) | LMNAKMT2AMEN1GLAALDH1A1 | |
| SCHEMBL19090470 | 0.84 | TSHR (0.44) | LMNAKMT2AMEN1GLAALDH1A1 | |
| SCHEMBL19090330 | 0.83 | ALDH1A1 (0.48) | LMNAKMT2AALDH1A1POLBHTT | |
| SCHEMBL19090314 | 0.77 | BRD4 (0.56) | LMNAKMT2AMEN1GLAALDH1A1 | |
| SCHEMBL19090318 | 0.76 | ELANE (0.41) | KMT2AMEN1ALDH1A1POLBTSHR | |
| SCHEMBL19090325 | 0.72 | ALDH1A1 (0.46) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL21389556 | 0.70 | BRD4 (0.54) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL21389515 | 0.68 | BRD4 (0.51) | LMNAKMT2AMEN1GLAALDH1A1 | |
| SCHEMBL21389535 | 0.67 | BRD4 (0.51) | LMNAKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL19090321 | 0.67 | BRD4 (0.46) | LMNAKMT2AMEN1GLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |