Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 18/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19099170 | 0.92 | MAP3K14 (0.49) | MAP3K14MAPK1 | |
| SCHEMBL19098731 | 0.89 | MAPK1 (0.55) | MAP3K14MAPK1MAPK6 | |
| SCHEMBL19099029 | 0.89 | MAPK1 (0.58) | MAP3K14MAPK1 | |
| SCHEMBL19098869 | 0.88 | MAPK1 (0.53) | MAPK1IKBKBMAPK6 | |
| SCHEMBL19099153 | 0.87 | MAPK1 (0.54) | MAPK1 | |
| SCHEMBL19098889 | 0.87 | MAPK1 (0.52) | MAPK1IKBKBMAPK6 | |
| SCHEMBL19099039 | 0.86 | MAPK1 (0.57) | MAP3K14MAPK1 | |
| SCHEMBL19099169 | 0.84 | MAPK1 (0.59) | MAP3K14MAPK1MAPK6 | |
| SCHEMBL19099027 | 0.84 | MAPK1 (0.58) | MAP3K14MAPK1MAPK6 | |
| SCHEMBL19098885 | 0.83 | IKBKB (0.63) | MAPK1IKBKBMAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922405-B | Compound with ERK kinase inhibitory activity, preparation method and application thereof | 中国科学院上海药物研究所 | 2021-02-19 | — | — | CN | disclosed |
| WO-2017114510-A1 | COMPOUND HAVING ERK KINASE INHIBITORY ACTIVITY, METHOD FOR PREPARATION THEREOF, AND USE THEREOF | 中国科学院上海药物研究所 | 2017-07-06 | — | — | WO | disclosed |