Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.53 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.51 |
| ▸ | SALL4 | Q9UJQ4 | 2/20 | 0.48 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413817 | 0.94 | CRBN (0.69) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL29488410 | 0.94 | CRBN (0.69) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL24601235 | 0.94 | CRBN (0.69) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL4449425 | 0.90 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL31726960 | 0.90 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL29614623 | 0.90 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL27305814 | 0.90 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL19612029 | 0.87 | CRBN (0.60) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL19612030 | 0.87 | CRBN (0.60) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL23535151 | 0.86 | CRBN (0.70) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399978-A1 | ANTIPROLIFERATIVE COMPOUNDS, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | Celgene Corporation (US) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017120422-A1 | ANTIPROLIFERATIVE COMPOUNDS, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | CELGENE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |