Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.73 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.63 |
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.59 |
| ▸ | SALL4 | Q9UJQ4 | 2/20 | 0.54 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449425 | 1.00 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL31726960 | 1.00 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL27305814 | 1.00 | CRBN (0.73) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL30930592 | 0.93 | CRBN (0.63) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL30984806 | 0.90 | CRBN (0.67) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL19100445 | 0.90 | CRBN (0.61) | CRBNDDB1IKZF2CSNK1A1SALL4 | |
| SCHEMBL21855270 | 0.90 | CRBN (0.77) | CRBNDDB1 | |
| SCHEMBL22034379 | 0.90 | CRBN (0.77) | CRBNDDB1 | |
| SCHEMBL29439987 | 0.90 | CRBN (0.77) | CRBNDDB1 | |
| SCHEMBL19792875 | 0.88 | CRBN (0.57) | CRBNDDB1IKZF2CSNK1A1SALL4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240743-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Prelude Therapeutics, Incorporated (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116669769-A | Piperidinyl small molecule degradants of HELIOS and methods of use | 达纳－法伯癌症研究所公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4110340-A1 | POTENT AND SELECTIVE DEGRADERS OF ALK | Dana-Farber Cancer Institute, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| CN-114650868-A | Small molecule degradation agent of HELIOS and use method thereof | 达纳-法伯癌症研究公司 | 2022-06-21 | — | — | CN | disclosed |
| WO-2022099117-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | PRELUDE THERAPEUTICS INCORPORATED (US) | 2022-05-12 | — | — | WO | disclosed |