Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIF5B | P33176 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18013058 | 0.82 | EGFR (0.59) | EGFRERBB2KDRRETKIF5B | |
| SCHEMBL19100471 | 0.82 | EGFR (0.48) | EGFRERBB2KDRRET | |
| SCHEMBL19100065 | 0.81 | EGFR (0.64) | EGFRERBB2KDR | |
| SCHEMBL19100047 | 0.73 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL20653216 | 0.72 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL19100193 | 0.71 | EGFR (0.68) | EGFRERBB2KDR | |
| SCHEMBL18012083 | 0.71 | KCNH2 (0.63) | EGFRERBB2KDR | |
| SCHEMBL19885271 | 0.71 | KDR (0.54) | EGFRERBB2KDRRETKIF5B | |
| SCHEMBL4461528 | 0.71 | EGFR (0.66) | EGFRERBB2KDRRETKIF5B | |
| SCHEMBL19100043 | 0.71 | EGFR (0.49) | EGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3400216-A1 | NOVEL FLUORINATED QUINAZOLINE DERIVATIVES AS EGFR INHIBITORS | Trillium Therapeutics Inc. (CA) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017117680-A1 | NOVEL FLUORINATED QUINAZOLINE DERIVATIVES AS EGFR INHIBITORS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-07-13 | — | — | WO | disclosed |