Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.66 |
| ▸ | FBP1 | P09467 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | KIF5B | P33176 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4127912 | 0.88 | FBP1 (0.64) | EGFRFBP1KDRRETKIF5B | |
| Hydrochloric Acid SCHEMBL1507513 | 0.87 | EGFR (0.63) | EGFRFBP1KDRRETKIF5B | |
| SCHEMBL27719215 | 0.85 | FBP1 (0.60) | EGFRFBP1KDRRETKIF5B | |
| SCHEMBL18013058 | 0.85 | EGFR (0.59) | EGFRFBP1KDRRETKIF5B | |
| SCHEMBL20709190 | 0.83 | RET (0.69) | EGFRFBP1KDRRETKIF5B | |
| Hydrochloric Acid SCHEMBL8681050 | 0.82 | EGFR (0.57) | EGFRFBP1KDRRETKIF5B | |
| SCHEMBL17967515 | 0.81 | EGFR (0.71) | EGFRKDRRETKIF5B | |
| SCHEMBL30777160 | 0.80 | EGFR (0.62) | EGFRFBP1KDRRETKIF5B | |
| SCHEMBL1657530 | 0.80 | EGFR (0.80) | EGFRFBP1ERBB2ERBB4 | |
| SCHEMBL20865216 | 0.78 | EGFR (1.00) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103076-A1 | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF RTK INHIBITORS | OXIGENE, INC. (US) | 2009-08-20 | — | — | WO | disclosed |