Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 15/20 | 0.65 |
| ▸ | KDM5A | P29375 | 8/20 | 0.65 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.65 |
| ▸ | KDM4A | O75164 | 1/20 | 0.65 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | KDM2B | Q8NHM5 | 9/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18612762 | 0.85 | KDM4C (0.69) | KDM4CKDM5AKDM5BKDM4APHF8 | |
| SCHEMBL18613077 | 0.84 | KDM4C (0.67) | KDM4CKDM5AKDM5BKDM4APHF8 | |
| SCHEMBL18612761 | 0.83 | KDM4C (0.67) | KDM4CKDM5AKDM5BKDM4AKDM2B | |
| SCHEMBL19101738 | 0.81 | KDM4C (0.71) | KDM4CKDM5AKDM5BKDM4APHF8 | |
| SCHEMBL18612871 | 0.80 | KDM4C (0.70) | KDM4CKDM5AKDM5BKDM4AKDM2B | |
| SCHEMBL16033660 | 0.79 | KDM4C (1.00) | KDM4CKDM5AKDM5BKDM4AKDM2B | |
| SCHEMBL18612738 | 0.78 | KDM4C (0.70) | KDM4CKDM5AKDM5BKDM4APHF8 | |
| SCHEMBL18612884 | 0.78 | KDM4C (0.70) | KDM4CKDM5AKDM5BKDM4APHF8 | |
| SCHEMBL19634840 | 0.78 | KDM4C (0.69) | KDM4CKDM5AKDM5BKDM4AKDM2B | |
| SCHEMBL22756753 | 0.78 | NPC1 (0.44) | KDM4CKDM5AKDM5BKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701657-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-07-11 | — | — | US | disclosed |