Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16708479 | 0.92 | TDP1 (0.35) | TMPRSS2TDP1NPC1RAB9ABRD4 | |
| SCHEMBL16708515 | 0.82 | TMPRSS2 (0.37) | TMPRSS2TDP1NPC1RAB9ABRD4 | |
| SCHEMBL19101768 | 0.82 | TMPRSS2 (0.42) | TMPRSS2TDP1 | |
| SCHEMBL19101885 | 0.81 | TMPRSS2 (0.37) | TMPRSS2TDP1NPC1RAB9A | |
| SCHEMBL19101754 | 0.81 | TMPRSS2 (0.40) | TMPRSS2TDP1NPC1RAB9AALDH1A1 | |
| SCHEMBL16708476 | 0.80 | SMN1; SMN2 (0.35) | TMPRSS2TDP1NPC1RAB9AALDH1A1 | |
| SCHEMBL16708478 | 0.80 | TMPRSS2 (0.39) | TMPRSS2TDP1NPC1RAB9A | |
| SCHEMBL16708474 | 0.79 | TMPRSS2 (0.34) | TMPRSS2TDP1NPC1RAB9A | |
| SCHEMBL18371670 | 0.79 | TMPRSS2 (0.39) | TMPRSS2TDP1NPC1RAB9AALDH1A1 | |
| SCHEMBL16708475 | 0.79 | TMPRSS2 (0.39) | TMPRSS2TDP1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701682-B2 | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-07-11 | — | — | US | disclosed |