Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13138246 | 0.67 | ATR (0.73) | ATR | |
| SCHEMBL17618321 | 0.58 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL24622110 | 0.57 | TDP1 (0.46) | — | |
| SCHEMBL16775745 | 0.56 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL24117937 | 0.56 | GAA (0.46) | — | |
| SCHEMBL608970 | 0.55 | MAOA (0.60) | — | |
| SCHEMBL12089871 | 0.55 | HPGD (0.55) | — | |
| SCHEMBL17623727 | 0.55 | MEN1 (0.47) | — | |
| SCHEMBL21221607 | 0.55 | MEN1 (0.43) | — | |
| SCHEMBL12564993 | 0.55 | KDM4E (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701674-B2 | Substituted pyrazines as ATR kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-07-11 | — | — | US | disclosed |