Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.42 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.42 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 7/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191171 | 0.94 | GRM5 (0.45) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL190744 | 0.92 | TRPV4 (0.47) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL191828 | 0.84 | GCK (0.54) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL191689 | 0.83 | GCK (0.52) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL190659 | 0.80 | GCK (0.59) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL191592 | 0.80 | TRPV4 (0.56) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL191025 | 0.79 | GCK (0.51) | GRM5TRPV4KCNN1KCNN2KCNN3 | |
| SCHEMBL191896 | 0.78 | MAPK8 (0.41) | RAB9AKMT2AMEN1NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL190962 | 0.77 | MAPK8 (0.40) | RAB9AKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL191056 | 0.77 | TRPV4 (0.56) | GRM5TRPV4KCNN1KCNN2KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |
| CN-101437512-A | Glucokinase activators | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |