Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19104287 | 0.87 | MAP2K4 (0.38) | MAPK1PRKAG1PRKAA1PRKAB1MAP2K4 | |
| SCHEMBL26577583 | 0.81 | MAPK1 (0.33) | MAPK1MAP2K4MAPK6MAPKAPK2MAPKAPK3 | |
| SCHEMBL22349131 | 0.78 | LMNA (0.45) | MAPK1DYRK1AFLT3LCKFYN | |
| SCHEMBL19786433 | 0.78 | MAPK1 (0.40) | MAPK1MAP2K4MAPK6MAPKAPK2MAPKAPK3 | |
| SCHEMBL17833922 | 0.77 | MAPK1 (0.35) | MAPK1MAP2K4MAPK6MAPKAPK2DYRK1A | |
| SCHEMBL19104285 | 0.74 | PDPK1 (0.42) | DYRK1AKDM4ECSNK2A1FLT3LCK | |
| SCHEMBL17030758 | 0.74 | MAPK1 (0.33) | MAPK1MAP2K4MAPK6MAPKAPK2DYRK1A | |
| SCHEMBL22328050 | 0.74 | MAPK1 (0.33) | MAPK1MAP2K4MAPK6MAPKAPK2 | |
| SCHEMBL19104228 | 0.74 | MAPK1 (0.33) | MAPK1MAP2K4MAPK6MAPKAPK2 | |
| SCHEMBL19104288 | 0.74 | MAP2K4 (0.35) | MAPK1MAP2K4MAPK6MAPKAPK2MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197945-A1 | 2-SUBSTITUTED QUINAZOLINE COMPOUNDS COMPRISING A SUBSTITUTED HETEROCYCLIC GROUP AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197945-A1 | 2-SUBSTITUTED QUINAZOLINE COMPOUNDS COMPRISING A SUBSTITUTED HETEROCYCLIC GROUP AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | MAPK1 197/4885PRKAG1 710/4885PRKAA1 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.