Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Linrodostat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 known ✓ | P14902 | 20/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 3/20 | 1.00 |
| ▸ | TDO2 | P48775 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Linrodostat SCHEMBL17740982 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL17747251 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL22808959 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL21354158 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL20620606 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL20620607 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL21354182 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL21354184 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL20971679 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 | |
| Linrodostat SCHEMBL29887589 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP2C8TDO2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127233-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL MYERS SQUIBB CO (US) | 2022-04-28 | — | — | US | disclosed |
| US-11236048-B2 | Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200123109-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL-MYERS SQUIBB COMPANY | 2020-04-23 | — | — | US | disclosed |
| WO-2019006292-A1 | SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-03 | — | — | WO | disclosed |
| US-20170197973-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES INC (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197973-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES INC (US) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236048-B2 | Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
| US-20200123109-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
| US-20170197973-A1 | IMMUNOREGULATORY AGENTS | IDO1, IDO2, INMT | IDO1 1/4885CYP2C9 2655/4885CYP2C8 1154/4885 |
| US-20220127233-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.