Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.35 |
| ▸ | PIM1 | P11309 | 11/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320431 | 0.82 | MAPT (0.37) | KDM4EPIM2PIM1PIM3KMT2A | |
| SCHEMBL1711977 | 0.81 | PIM1 (0.44) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL318608 | 0.80 | KDM4E (0.50) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL29533318 | 0.80 | KDM4E (0.50) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL319604 | 0.79 | XDH (0.36) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL12077498 | 0.78 | MGAM (0.35) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL12488326 | 0.78 | ECE1 (0.34) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL1711990 | 0.78 | KDM4E (0.53) | KDM4EALOX15PIM2PIM1PIM3 | |
| SCHEMBL29599851 | 0.78 | KDM4E (0.53) | KDM4EALOX15PIM2PIM1PIM3 | |
| SCHEMBL319715 | 0.77 | MYC (0.38) | KDM4EALOX15TSHRACMSDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |