Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 5/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29326802 | 0.78 | CDK2 (0.56) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL23815649 | 0.70 | CDK2 (0.79) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19112174 | 0.69 | CDK2 (0.58) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19112162 | 0.66 | TAAR1 (0.58) | METAP2METAP1 | |
| SCHEMBL19112166 | 0.65 | CDK2 (0.72) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL15372679 | 0.64 | CDK2 (0.78) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19112097 | 0.63 | CDK2 (0.75) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19111955 | 0.63 | CDK2 (0.75) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19139043 | 0.63 | CDK2 (0.75) | CDK2CDK5CCNE1CCNA2CCNA1 | |
| SCHEMBL19112176 | 0.63 | CDK2 (0.61) | CDK2CDK5CCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2664619-B1 | Purine derivatives as tools for screening anti-Alzheimer compounds | MANROS THERAPEUTICS (FR) | 2017-07-12 | — | — | EP | disclosed |